Arthur de Jong and Matthijs Verhage publish a study on how adjustments of synaptic strength depend on the phosphorylation of Synaptotagmin-1, the major calcium-sensor for transmitter release.

Epileptic seizures arise when the activity of the brain gets out of control. A large research team at CNCR has investigated how the brain controls its activity and identified a new molecular pathway involving the synaptic protein Munc18-1 that helps the brain to slow down when activity gets too high. The study appeared in EMBO Journal.

Ruud Toonen, in collaboration with Prof. Hoogenraad (UU, Utrecht) and Dr. Rüdiger (UU, Utrecht), receives a 670k€ ZonMW TOP grant to study the role of axonal transport in neurodegenerative diseases.